Of course a big part of any further stories will have to be Mary’s future. Mary would definitely need to come into her own even more, more independence, more agency. She will become more and more important to Mrs. Hawking’s work, to the point where she is not totally just the protege and able to contribute more on her own.
She also will have to develop separately from the path of Mrs. Hawking. I’d love Mary to eventually meet someone and have a romance with a gentleman who was worthy of her, who of course Mrs. Hawking would despise because she would hope Mary to be a confirmed lone wolf like herself. I think a major issue to sort out will be that while the women compliment each other, they are also extremely different from each other, and those differences will sometimes make it difficult to always work in harmony together. I think that will be a great source of dramatic tension.
Honestly, in many ways the story is Mary’s more even than Mrs. Hawking’s. She is, you will notice, the only character in every single scene in the original piece. Mary turned out to be even more central and significant than I ever expected, so I would want her to continue to grow and develop, and, as she proved to be remarkably good at, to force Mrs. Hawking to do the same.